PAX8 | ONCOdianova

Clone JAX8 validated for IHC detection of PAX8 transcription factor in routine-fixed FFPE tissue sections

PAX8 antibody

Fig.02 Strong nuclear PAX8 positivity in a benign thyroid adenoma.

Fig.03 Benign thyroid adenoma with strong nuclear and - to a lesser extent - cytoplasmic PAX8 staining.

Fig.04 Follicular thyroid carcinoma with strong nuclear and cytoplasmic PAX8 staining. The complete absence of stromal staining indicates the tumor-specificity of PAX8 staining.

Fig.05 Strong PAX8 staining in a papillary thyroid carcinoma.

Fig.06 Clear cell renal cell carcinoma with nuclear PAX8 staining

Fig.07 Papillary renal cell carcinoma with intense nuclear and cytoplasmic PAX8 staining. The complete abscence of staining in the stroma underscores the specificity of tumor staining.

Fig.08 Papillary renal cell carcinoma with intense PAX8 staining.

Fig.09 Papillary renal cell carcinoma with PAX8 staining.

Fig.10 Moderately strong nuclear PAX8 positivity in a chromophobic renal cell carcinoma.

Fig.11 Strong nuclear and cytoplasmic PAX8 positivity in a mucinous ovarian carcinoma.

Fig.12 Endometrioid ovarian carcinoma with strong nuclear PAX8 positivity.

Fig.13 Strong nuclear PAX8 positivity in a serous ovarian carcinoma.

Fig.14 Serous ovarian carcinoma with strong nuclear and cytoplasmic PAX8 positivity.

Fig.15 Endometrioid endometrial carcinoma with strong PAX8 staining (nuclear and cytoplasmic).

Fig.16 Strong nuclear PAX8 positivity in a serous endometrial carcinoma.

Fig.17 Urothelial carcinoma with clear nuclear PAX8 staining.

Fig.18 Epithelium of the uterine tuba with clear nuclear PAX8 staining.

PAX8 is a member of the paired box (PAX) family of transcription factors involved the regulation of early development of the thyroid gland, kidney, and Mullerian tract. PAX8 plays a central role for the expression of thyroid-specific genes and thus, in development of thyroid follicular cells. Mutations in the PAX-8 gene are linked to thyroid follicular carcinomas. In the developing kidney PAX8 is important for renal vesicle formation.

PAX8 is highly expressed in several neoplasms: Epithelial tumors of the thyroid and parathyroid glands, kidney, thymus, pancreatic neuroendocrine tumors and female genital tract. Follicular and papillary thyroid carcinoma are almost always PAX8 positive (while medullary thyroid carcinoma is negative, but anaplastic carcinoma is positive in most cases). PAX8 is also found in almost all cases of endometrial carcinoma and ovarian serous, endometrioid, transitional and clear cell carcinoma. Moreover, PAX8 is found in most cases of renal cell carcinoma (all types) and in oncocytoma as well as in thymic tumours. Different reports have shown that adenocarcinomas of lung and breast are negative for PAX8-expression. Also, PAX-8 is not found in the epithelial cells of the breast, lung, mesothelium, stomach, colon, pancreas.

PAX 8 is a useful IHC marker with a wide range of diagnostic applications and appears to be the most specific and sensitive marker for renal cell carcinoma and ovarian non-mucinous carcinoma.

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